Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

Abstract. Arab Y, Sahin B, Ceylan O, Zellagui A, Olmez OT, Kucukaydin S, Tamfu AN, Ozturk M, Gherraf N. 2022. Assessment of in vitro activities and chemical profiling Senecio hoggariensis growing Algerian Sahara. Biodiversitas 23: 3498-3506. The antioxidant, anticholinesterase, tyrosinase inhibitory, antibiofilm, anti-quorum sensing the ethyl acetate extract hoggariensis,growing Sahara, were studied along with its constituents using HPLC-DAD. chromatographic analysisunveiled seven phenolic compounds, including p-coumaric acid as a major component. Additionally, showed moderate DPPH radical scavenging activity, compared to known standards. At 200 ?g/mL, disclosed equitable acetylcholinesterase (AChE), butyryl-cholinesterase (BChE) inhibition rates respective values 37.01±1.48%, 18.87±4.18% 45.99±1.81%. Likewise, exhibited good antibiofilm activity against Candida albicans ATCC 10239 biofilm production an ratio 59.56±0.40%, at 50µg/mL. by QS-regulated violacein pigment test was determined Chromobacterium violaceum CV026 CV12472. swarming motility assay Pseudomonas aeruginosa PA01. It is evident from findings that could be considered potential anti-QS, compounds. However, origin anti-biofilm revealed further studies on mechanism action active compounds can isolated via activity-guided fractionation.